On 28th December 1998, the company was formed.
On 8th March 1999, the first phase construction project commenced. The project was completed in September and put into trial operation in October of the same year. The goal of building the factory, beginning operation and exporting products abroad within one year was achieved.

In October 2000, the company passed the GMP certification by the National Drug Administration, being the first bio-chemical and pharmaceutical factory to pass this certification in China. In December of that year, the company was designated a hi-tech enterprise by the Science and Technology Bureau of Shandong Province, and the company’s products were listed on the Catalogue of “Chinese Hi-tech Products export lists” by the State Ministry of Science and Technology.

In 2001, Company export products reached 11 million USD. And in September of the same year, the achieved ISO9002 quality system accreditation, making it the first bio-chemical & pharmaceutical factory in China to receive such certification.

In 2002, Company exports reached 12 million USD. In May, the company passed the re-inspection of GMP certification by the National Drug Administration. The second phase construction project began in October. In November, Yantai Beifang Pharmaceutical Co., Ltd became part of the company holdings.

In 2003, Company exports totaled 13 million USD. ISO9001：2000 (new revision) certification of was successfully obtained in May. The second phase project was put into operation in July, and the company completed the US FDA registration and obtained a DMF register number in December.

In 2004, Company exports totaled 11 million USD. A third phase bio-engineering workshop construction project was completed and put into operation.

In January 2005, the company obtained the COS certificate issued by EU for its heparin product.